By placing multi-stakeholder collaboration at the heart of innovation, Living Labs play a transformative role in addressing pressing societal challenges. These include the complexities of ageing societies, widening socio-economic health disparities and transforming (clinical) care and everyday living environments. Living Labs have the potential to make significant contributions to health and wellbeing and creating smart healthy environments. This conference will showcase state-of-the-art research that explores Living Labs as pivotal ecosystems for transforming all areas of health and wellbeing, including clinical care, smart environments, disease management, public health and prevention to name a few.